摘要
用不同浓度含锌培养液在体外培养小鼠脾脏淋巴细胞。当锌浓度在0.12～0.5×10^(-4)mol/L时,~3H-TdR掺入淋巴细胞量明显增加;与分裂原共同培养时,锌明显促进淋巴细胞对ConA和LPS的增殖反应,其促增殖的最佳浓度为0.12×10^(-4)mol/L。锌浓度在1.0×10^(-4)mol/L以上时呈现对细胞的毒性作用。锌还促进混合淋巴细胞反应;增强胸腺细胞对IL-1的增殖反应。
The spleno-and thyme-lymphocytes of mice were cultured in the media with various concentrations of zinc. The results showed that zinc acted as a weak mitogen and stimulating lymphocyte proliferation at 0.12-0.5× 10-4 mol/L. It also enhanced the lymphocyte proliferation to Con A and LPS. The optimal concentration was 0.12×10-4mol/L. It enhanced the MLR of spleno-lym-phocyte and increased the responsive ability of thymocyte to IL-1. Zinc was poisonous to cells at concentrations higher than 1.0 ×10-4mol/L.
出处
《营养学报》
CAS
CSCD
北大核心
1993年第3期275-279,共5页
Acta Nutrimenta Sinica
关键词
锌
免疫功能
zinc immune function
