温通散对糖尿病肢端坏疽早期病变的影响

Effect of Wentongsan powder on the treatment of early lesion of diabetic acromelic gangrene

目的 观察温通散治疗糖尿病肢端坏疽早期病变的疗效 ,并探讨其改善患者下肢血管神经病变的机制。方法 5 4例 2型糖尿病早期肢端病变患者在内科一般治疗的基础上 ,治疗组 30例外用温通散水煎剂泡足 ,对照组 2 4例予高锰酸钾稀释液泡足 ,共治疗 3个月 ,观察 2组临床症状、血液流变学、下肢血管彩色多普勒超声的变化。结果 治疗组在改善肢端感觉、疼痛、皮温诸症和踝 臂血压指数、血浆黏度、纤维蛋白原及下肢动脉内膜、血流量方面明显优于对照组 (P <0 .0 5 )。结论 温通散对于防治糖尿病肢端坏疽早期病变有一定的疗效 。

Objective To investigate the effect of Wentongsan powder on the treatment of early lesion of diabetic acromelic gangrene and research the mechanism of improving limbal vascular neuropathy of diabetes. Methods 54 cases with early limbal lesion of diabetes were divided into two groups. Patients in control group (n=24) were treated by combination of routine therapy and external therapy of Potassium Permanganate. Patients in treatment group (n=34) were treated by Wentongsan powder combined with routine therapy. The course in both groups was 3 months. To evaluate the effect, symptoms, indexes of hemorrheology and color Dopple were observed. Results Improvement of symptoms, hemorrheology and color Dopple on treatment group were superior to those of control group (P<0.05). Wentongsan powder has obviously effect in treating early lesion of diabetic acromelic gangrene.