烧伤大鼠血浆和肝脏硒的变化及补充硒对维生素E的影响

A STUDY ON CHANGES OF PLASMA AND LIVER SELENIUM AND THE EFFECT OF SELENIUM SUPPLEMENTATION ON VITAMIN E IN BURNED RATS

本研究用Wistar雄性大鼠背部体表面积约20％的三度烧伤为模型。烧伤后,血浆、肝脏硒的浓度降低,与硒有关的谷胱甘肽过氧化物酶的活性减小,同时血浆VE明显降低,而RBC和肝脏VE的含量并没有降低。伤后每天补充2.3μgSe/100gbw的亚硒酸钠,RBC和肝脏VE的含量明显低于正常对照组,血浆VE也较烧伤不补硒组低,同时使血浆总巯基的含量降低更为明显。结果表明,烧伤后补充硒可使VE的消耗增多。

The selenium levels in plasma and liver of rats suffered from 3rd degree burn of 20% BSA on dorsum were significantly decreased, plasma VE dropped too, while the VE contents of RBC and liver were as high as those in control group. After giving 2.3μg selenium/100g bw as selenite to the burned rats, the VE contents of RBC and liver as well as plasma were then decreased as compared with control. The content of plasma total sulfhydryl group decreased more in selenium-supplemented group than in burned control.These results indicated that the requirement of VE probably increased after supplementation of selenium in burned rats.