摘要
在体外γ－亚麻酸抑制人神经母细胞瘤细胞的生长，诱导其表型发生逆转，抑制人结肠癌，人胃癌和人胰癌细ＤＮＡ的合成，但却不抑制１２－０－十四酰佛波－１３－１乙酸酯（ＴＰＡ）增强细胞对己糖的摄入和＾３Ｈ掺入细胞磷脂的作用。在体内γ－亚麻酸抑制二甲基苯并蒽（ＤＭＢＡ）激发的、ＴＰＡ促进的小鼠皮肤乳头状瘤的发生。
In vitro tests showed thatγ-linolenic acid inhibited the growth of human neuroblastoma cells (GOTO), induced its phenotypic reversion, and suppressed DNA synthesis in human colon carcinoma cells (COLO320DM), human gastric cancer cells (HGC-27) or human pancreatic cancer cells (PANC-I), but did not inhibit 12-O-tetradecanoylphorbol-13-acetate(TPA)-stimulated hexose transport in Swiss 3T3 mouse fibroblasts and 3H-incorporation into phospholipids in C3HlOTl/2 clone 8 cells. In vivo study it exhibited that γ-linolenic acid suppressed the promoting effect of TPA on skin tumor formation in mice initiated with 7, 12-dimethylbenz (a)anthracene (DMBA).
出处
《营养学报》
CAS
CSCD
北大核心
1993年第4期390-396,共7页
Acta Nutrimenta Sinica
基金
陕西省卫生厅资助项目
