脑损伤修复与成体干细胞的可塑性(英文)

Plasticity of adult stem cells in the rehabilitation of brain injury

目的:成体干细胞体在内外可分化为神经细胞而用于脑损伤修复,探讨成体干细胞用于脑损伤康复的可行性可为脑功能恢复的临床实践提供前瞻性依据。资料来源:应用计算机检索Medline1998-01/2004-04和PubMed1998-01/2004-04期间的相关文章,检索词stemcell,cerebralinjury,“rehabilitation,并限定文章语言种类为English。同时计算机检索中国临《床康复》杂志1997-01/2004-04期间的相关文章,限定文章语言种类为中文,检索词“干细胞、脑损伤、康复”。资料选择:对资料进行初审,选取包括成体干细胞分化为神经细胞及其用于脑损伤治疗的实验和临床研究文献,查找文献全文。资料提炼:共收集到33篇关于成体干细胞可塑性分化及其用于脑损伤的研究文献。资料综合:33篇文献证明了成体干细胞可分化为神经细胞及其可能的机制,并证明了成体干细胞移植治疗脑损伤的有效性。结论:已有研究充分证明成体干细胞在体内外可分化为神经细胞,并可用于脑损伤的修复。

OBJECTIVE:Adult stem cells(ASCs) have been applied to the rehabilitation of br ain injury for its capability of differentiation into neural cells both in vitro and in vivo,thereby to explore the feasibility of application of ASCs to the re habilitation of brain injury could provide prospective basis for clinical practi ce in brain functional recovery. DATA SOURCES:Relative articles were computer searched in Medline and PubMed b etween January 1998 and April 2004 ,with the key word of “stem cell,cerebral in jury, rehabilitation 'and language limited to English.Meanwhile similar articles in Chinese Journal of Clinical Rehabilitation from January 1997 to April 2004 w ere also searched with the same keywords in Chinese. STUDY SELECTION:Literatures concerning the differentiation of ASCs into neural cells,as well as experimental and clinical studies on their application in brai n injuries were adopted after first trial. Furthermore their whole articles were lookedup. DATA EXTRACTION:Totally thirty three literatures concerning the plastic diffe rentiation of ASCs and their application to brain injury were finally enrolled i n the study. DATA SYNTHESIS:All these literatures demonstrated the possible differentiation mechanism of ASCs into neural cells,as well as the efficacy of ASCs in the tran splant treatment for brain injury. CONCLUSION:Previous reports fully demonstrated that ASCs could differentiate i nto neural cells and could be used in the rehabilitation of brain injury.