急性冠状动脉综合征患者外周血基质金属蛋白酶-9水平变化

Change of matrix metalloproteinase-9 in patients with acute coronary syndrome

检测急性冠脉综合征(ACS,acute coronary syndrome)患者入院前血浆基质金属蛋白酶-9(MMP-9)水平,并同稳定心绞痛相比较,以了解其是否可为预测动脉粥样硬化(AS,atherosclerosis)斑块不稳定性提供简捷、方便的方法.研究方法:用双抗体酶联免疫法检测不稳定性心绞痛(UA,unstable angina)24例,急性心肌梗塞(AMI,acute myocardialinfarction)24例,稳定性劳累心绞痛(EA,effort angina)17例,正常对照17例血浆MMP-9水平.结果:各实验组外周血MMP-9水平不同(F=12.56,P=0.000),EA患者较正常对照组升高,但未达统计学意义(F=0.606),UA组高于EA组(P=0.03),AMI组高于EA组(P=0.041),UA组明显高于正常对照组(P=0.001),AMI组也明显高于对照组(P=0.003),UA组与AMI组MMP-9水平差别无统计学意义(P=0.289).结论:ACS时外周血MMP-9水平比对照组和EA组明显升高,MMP-9水平是预测AS斑块不稳定性的方法.

Matrix matalloproteases (MMPs), especially MMP-9, play an essential role in the disrupture of atherosclerosis plaque, which may result in acute coronary syndrome including unstable angina, acute myocardial infaction and sunden death. The MMP-9 can specially degrade the basic membrane, which is necessary to pass through the basic membrane. Recent research into the expression of MMPs in body fluid is limited. Therefore, this study is to investigate the level of MMP-9 in patients with ACS to learn whether we may provide a convenient and simple method for predicting the unstability of AS lesion. Methods: To use the ELISA to investigate the level of patients with UA(24), AMI(24), EA(17), control(17). Results: The level of MMP-9 is increased in patients with ACS compared with EA and control groups. Conclusion: Measuring MMP-9 might be a convenient and efficient method to predict the unstability of AS plaque.