纳洛酮对急性有机磷中毒者肝脏保护作用的研究

The liver protection of Naloxone on patients with acute organophosphorus pesticide poisoning

目的 研究纳洛酮对急性有机磷农药中毒患者肝脏功能的影响及其意义。方法 对 5 2例有机磷农药中毒患者按入院顺序随机分实验组 (2 7例 )和常规组 (2 5例 ) ,两组基础治疗相同 ,实验组给予纳洛酮 0 .8～ 1.2mg静脉注射 ,疗程 3～ 10d。分别动态监测各组血清丙氨酸氨基转移酶 (ALT)、天门冬氨酸氨基转移酶 (AST)的变化。结果 实验组治疗 72h后血清ALT及AST水平均比常规组明显下降 (P均 <0 .0 1) ,治疗总有效率也明显高于对照组 (χ2 =9.2 7,P <0 .0 1)。结论 纳洛酮对急性有机磷农药中毒患者肝损害具有保护作用。

Objective To study the therapeu ti c effect and significnce of Naloxone on the liver function on patients with acut e organophosphorus pesticide poisoning. Methods 52 patients with acute organophosphoru s pesticide poisoning were randomly allocated to two groups according to the hos pitalized date, the experimental group (n=27) and the normal group (n=25). The t wo groups received the same basal treatment, and the experimental group were giv en additional treatmnet with 0.8～1.2mg Naloxone, intravenous injection, the tre a tment course lasted for 3～10 days. Dynamic monitoring the changes of the ALT an d AST levels in each groups, respectively. Results 72 hours after treatment, the serum le vels of ALT and AST in the experimental group were higher than those in the norm al group (all the P values were<0.01). The therapeutic effect was obviously better than that in the control group (χ 2=9.27,P<0.01). Conclusion Naloxone can protect the injured li vers in patients with acute organophosphorus pesticide poisoning.