类风湿性关节炎致肺功能损害的研究

The study of lung function injury induced by rheumatoid arthritis

目的 研究类风湿性关节炎 (RA)致肺功能损害的变化。方法 采用日本产ChestGrophHI -70 1型体积容积描记肺功能仪检测 5 8例RA组患者的肺功能情况 ,设 5 8例非吸烟健康者作为对照组。结果 RA组弥散功能明显受损(P均 <0 .0 1) ,弥散功能异常率为 62 .0 7% ,小气道阻塞为 48.2 8% ,肺气肿为 43 .10 % ,通气功能减退为 3 2 .76% ,阻塞性通气障碍为 3 2 .76% ,限制性通气障碍为 3 6.2 1%。结论 RA患者的肺功能损害以弥散功能减退为主 ,其次为小气道阻塞、肺气肿、通气功能减退 ,对早期肺损害诊断有重要意义。

Objective To investigate the ch anges of the lung injury caused by rheumatoid arthritis. Methods The lung function in 58 patients with rheumatoid arthritis (RA group) were measured by a Chest Groph type HI-701 lung function plethysmograph,produced in Japan. 58 non-smoking normal individuals wer e selected in the control group. Results The diffusion function in RA group wer e significantly obstructed (all P<0.01), the abnormality rate of diffusion w as 6 2.07%, the rate of small airway obstruction was 48.28%, the pulmonary emphysemia was 43.10%, the ventilation function decrease was 32.76%, the obstructive venti latory disturbance was 32.76%, and the restrictive ventilatory functional distur bance was 36.21%. Conclusion In patients with rheumatoid arthrit is, the diffusion decrease ranked first in lung injuries, the next were small ai rway obstruction, pulmonary emphysema, ventilation function decrease, all of whi ch are of importance for the diagnosis of early lung injuries.