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质子泵与胃酸分泌的研究进展 被引量：1

Overview of proton pump and gastric acid secretion research
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摘要 质子泵是胃酸分泌过程中的关键酶 ,由α、β亚单位构成 ,通过分解ATP提供能量 ,逆浓度梯度将H+ 泵出细胞。质子泵的表达和活性呈明显的发育性变化。组胺、胃泌素、生长抑素等激素作用于相应受体 。
作者 石志敏 赵茹茜
机构地区 南京农业大学农业部动物生理生化重点开放实验室
出处 《畜牧与兽医》 北大核心 2005年第1期50-52,共3页 Animal Husbandry & Veterinary Medicine
基金 国家自然科学基金资助 (30 2 70 975)
关键词 质子泵 胃酸 调节
分类号 S852.3 [农业科学—基础兽医学]
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参考文献16

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  • 2Spicer Z, Miller M L, Andringa A, et al. Stomachs of mice lackingthe gastric H, K-ATPase α-subunit have achlorhydria, abnormal parietal cells, and ciliated metaplasia [ J ]. Journal of Biological Chemistre, 2000, 275(28): 21555-21565.
  • 3Besancon M, Simon A, Sachs G, et al. Sites reaction of the gastric H, K-ATPase with extracytoplasmic thiol regents [J]. Journal of Biological Chemistre, 1997, 272: 22438-22446.
  • 4Asano S, Matsuda S, Tega Y, et al. Mutational analysis of putative SCH28080 binding sites of the gastric H + -K + -ATPase[J]. Journal of Biological Chemistre, 1997, 272 : 17668-17674.
  • 5Xiaoyan Jiang, Etsuko Suzaki, Katsuko Kataoka. Immunofluorescene detection of gastric H^+/K^+ -ATPase and its alteration as related to acid secretion [J]. Histochem Cell Biol, 2002, 117: 21-27.
  • 6Lennart friis-hansen. Impaired gastric acid secretion in gastrin-deficient mice [J]. Am J Physiol, 1998, 274(37) : G561-G568.
  • 7Yuki H, Nishida A, Miyake A, et al. YM022, a potent and selective gastrin/CCK-B receptor antagonist, inhibits peptone meal-induced gastric acid secretion in Heidenhain pouch dogs E J 1. Dig Dis Sci,1997, 42(4): 707-714.
  • 8Langhans N, Rindi G, Chiu M. Abnormal gastric histology and decreased acid production in cholecystokinin-B/ gastrin receptor-deftcient mice [J]. Gastroenterology, 1997, 112(1): 280-286.
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同被引文献27

  • 1NIKLASSON A,LINDSTRM L,SIMRN M,et al.Dyspepticsymptom development after discontinuation of a proton pump in-hibitor:a double-blind placebo-controlled trial[J].Am J Gastro-enterol,2010,105(7):1531-1537.
  • 2KISHOR SJ,ANAMIK KS,JITENDER B,et al.Recent ad-vances in proton pump inhibitors and management of acid-pepticdisorders[J].Bioorg Med Chem,2007,15(3):1181-1205.
  • 3KEIICHI I,KAZUYA K,ATSUYUKI T.et al.The effect ofsubchronic administration of 7-(4-fluorobenzyloxy)-2,3-dimeth-yl-1-{[(1S,2S)-2-methylcyclopropyl]methyl}-1H-pyrrolo[2,3-d]pyridazine(CS-526),a novel acid pump antagonist,on gas-tricacid secretion and gastrin levels in rats[J].JPET,2008,326(1):163-170.
  • 4MALINOWSKA DH,SHERRY AM,TEWARI KP,et al.Gas-tric parietal cell secretory membrane contains PKA-and acid-acti-vated Kir2.1 K+channels[J].Am J Physiol Cell Physiol,2004,286(3):495-506.
  • 5LAMBRECHT NW,YAKUBOV I,SCOTT D,et al.Identifica-tion of the K efflux channel coupled to the gastric H+,K+AT-Pase during acid secretion[J].Physiol Genomics,2005,21(1):81-91.
  • 6WALLMARK B,JARESTEN BM,LARSSON H,et al.Differen-tiation among inhibitory actions of omeprazole,cimetidine,andSCN-on gastric acid secretion[J].Am J Physiol,1983,245(1):67-71.
  • 7JAUNIN P,HORISBERGER JD,RICHTER K,et al.Process-ing,intracellular transport,and functional expression of endoge-nous and exogenousα-β3 Na+,K+-ATPase complexes in Xeno-puso ocytes[J].J Biol Chem,1992,267(1):577-585.
  • 8LAURENCE V,JEAN MR,ERIK G.Fourier transform infraredspectroscopy study of the secondary structure of the reconstitutedneurospora crassa plasma membrane H+,K+-ATPase and of itsmembrane-associated proteolytic peptides[J].J Biol Chem,1995,270(30):17685-17696.
  • 9LI W,YANG Y,TIAN Y,et al.Preparation and in vitro/in vivoevaluation of revaprazan hydrochloride nanosuspension[J].Int JPharm,2011,408(1-2):157-162.
  • 10ANDERSSON K,CARLSSON E.Potassium competitive acidblockade:a new therapeutic strategy in acid related diseases[J].Pharmacol Ther,2005,108(3):294-307.

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畜牧与兽医
2005年 第1期

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