C-myc和CD44/HCAM在卵巢上皮性肿瘤中的表达

Expressions of C-myc and CD44/HCAM in ovarian epithelial tumor and clinical significance

目的探讨C myc蛋白、CD4 4黏附分子在卵巢上皮性肿瘤中的表达和临床意义。方法应用免疫组化法检测 30例卵巢恶性上皮性肿瘤 ,4例卵巢交界性肿瘤 ,12例卵巢良性上皮性肿瘤 ,10例正常卵巢组织中的C myc、CD4 4 /HCAM的表达 ,及其与病理分期、临床分期的相关性。结果恶性和交界性卵巢上皮性肿瘤中C myc基因蛋白和CD4 4 /HCAM的阳性表达率比良性肿瘤和正常卵巢的表达明显增高 ;不同组织学类型和不同分化程度卵巢上皮性癌中的C myc和CD4 4 /HCAM的阳性表达率无明显差异 ;Ⅰ期与Ⅰ期以上者C myc的阳性表达率无明显差异 ,而CD4 4 /HCAM的阳性表达率有明显差异 (P <0 .0 5 )。结论卵巢肿瘤组织中C myc和CD4 4 /HCAM的表达 ,与卵巢肿瘤的发生有密切关系 ;CD4 4 /HCAM的高表达可能与卵巢肿瘤细胞盆腹腔种植有关。

Objective To investigate the expression and clinical significance of C-myc gene and CD44/HCAM adhesion molecular in the ovarian epithelial tumor. Methods To detect the expression of C-myc and CD44/HCAM in 30 ovarian malignant epithelial tumors, 4 ovarian borderline tumors,12 ovarian benign tumors and 10 normal ovarian tissues with immuno-histochemical method, and their co-relations with pathological and clinical stage. Results The positive expression rate of C-myc and CD44/HCAM in malignant and borderline ovarian epithelial tumor is higher than in benign tumors and normal ovarian tissues. There is no significant difference of C-myc and CD44/HCAM positive expression between various histological types and different differentiation degree in ovarian epithelial tumor. C-myc positive expression rate shows no difference between clinical stage I and stages Ⅱ～Ⅳ, however, CD44/HCAM positive expression rate is significantly different among different stages (P<0.05). Conclusion The expression of C-myc gene and CD44/HCAM is correlated with the pathogenesis of ovarian tumors. The high expression rate of CD44/HCAM may indicate the possibility of pelvic and abdominal tumor implantation.