托吡酯与丙戊酸钠对隔离小鼠攻击行为自主活动的影响

The effects of topiramate and valproate sodium on spontaneous motor activity behavior and isolation-induced aggression in mice

目的研究托吡酯与丙戊酸钠对小鼠隔离攻击行为以及自主活动的影响,为其作为攻击行为的图表1治疗药物提供实验依据。方法建立隔离小鼠攻击模型。将筛选出来的有攻击行为的隔离小鼠随机分为4组,每组10只,分别给予不同剂量的托吡酯(25mg/kg、50mg/kg、100mg/kg)与丙戊酸钠(50mg/kg、100mg/kg、200mg/kg),于灌胃后120min(托吡酯)、或于腹腔注射30min(丙戊酸钠)后评价它们的作用。结果丙戊酸钠托吡酯呈剂量依赖性延长攻击潜伏期和降低其自主活动能力。结论丙戊酸钠和托吡酯均具有抗隔离小鼠攻击行为的药理活性,而且托吡酯和丙戊酸钠在抗攻击行为上具有协同效应。

Objective:To study the effects of valproate sodium and topiramate on spontaneous motor activity behavior and isolation-induced aggression in mice,and thus to provide evidence for drug treatment.Methods:Male Kunming mice were isolated for 40～45days as an animal model of isolation-induced aggression.The isolated and group-housed mice were administrated with different doses of valproate sodium (0mg/kg、50mg/kg、100mg/kg、200mg/kg) and topiramate(0mg/kg、25mg/kg、50mg/kg、100mg/kg).The aggressiveness of isolated mice was measured 30min after the administration of valproate sodium or 120min after the administration of topiramate.Results:Valproate sodium and topiramate could dose-dependently prolong the latencies to attacking.They could also decrease spontaneous motor activity.Conclusion:Both valproate sodium and topiramate are inhibitors of aggression behavior in isolated mice.Topiramate and valproate sodium have synergism.