双黄补缓释药条对实验性牙周组织再生的研究

The study of shuanghuangbu delivery device in experimental regeneration of periodontium

目的探讨双黄补缓释药条对实验性牙周组织再生修复的作用。方法以4只Beagle犬双侧上下颌第二切牙及尖牙作为手术部位,共32个,将其配对分组为实验组和对照组各16个牙位。实验部位经翻瓣术造成人工牙周骨缺损,应用双黄补缓释药条,对照组为单纯翻瓣术;分别于术后1个月和3个月做组织学观察以及新生牙槽骨、新生牙骨质、结合上皮长度的测量。结果实验组术后1个月和3个月新生牙槽骨和牙骨质明显大于对照组的相应值(P<0.05);术后1个月实验组结合上皮长度明显短于对照组(P<0.05),而术后3个月两组JE值差异无显著性意义(P>0.05)。结论双黄补缓释药条可促进实验动物新生牙槽骨和牙骨质的生长,抑制结合上皮根移,有利于牙周组织再生。

Objective:To discuss the effect of shuanghuangbu delivery device on the regeneration of the experimental periodontium.Methods:The second incisor and the canine of four beagle dogs were randomly divided into the experimental group and the control group.Shuanghuangbu was applied to periodontal defect in the experimental group and no disposition to periodontal defect in the control group.The specimens were respectively obtained in one month and three months after operation and then observed.Furthermore,the height of new bone and cementum formation and the length of junctional epithelium were measured in the two groups.Results:The heights of new bone and cementum regeneration in the experimental group were extremely bigger than those in the control group on one month and three months postoperatively ( P <0.05).The length of junctional epithelium of the experimental group were less than that of the control group on one month postoperatively( P <0.05),but there was no significant difference between two groups on three months ( P >0.05).Conclusion:Shuanghuangbu can obviously promote the new bone and cementum formation,restrain the migration of junctional epithelium and enhance the regeneration of periodontal tissue.