下肢Buerger’s病患者腰交感神经节神经元中DBH的改变

Changed DBH expression of the neurons in lumbar sympathetic ganglia in response to Buerger's disease of lower limb

目的研究下肢Buerger’s病患者腰交感神经节神经元中去甲肾上腺素合成酶——多巴胺-β-羟化酶(dopaminebetahydroxylase,DBH)的表达。方法采用免疫组织化学SP法检测14例Buerger’s病患者和11例非Buerger’s病患者腰交感神经节神经元中DBH的表达水平。结果Buerger’s病患者神经元内DBH表达有高于正常人的总体趋势,差异具有统计学意义(P<0.05)。结论DBH的表达增强可使血管更多的处于痉挛状态,促进了本病的发生发展。

Objective:To observe the expression of dopamme beta hydroxylase (DBH) in the lumbar sympathetic ganglia neurons of the patients with Buerger's disease of lower limb.Methods:The DBH expression of the neurons in lumbar sympathetic ganglia of 14 patients with Buerger's disease were observed by immunohistochemistry staining.11 patients without it served as the controls.Results:The DBH expression of the patients were reinforced that of control group.Conclusion:The enhanced expression of DBH may result in vasospasm,accelerating the development of Buerger's disease.