谷氨酸脱羧酶抗体测定在糖尿病分型中的临床意义

Clinical significance of measuring GAD antibody in determining the type of diabetes

目的 探讨谷氨酸脱羧酶抗体测定在糖尿病分型中的临床意义。方法 应用酶联免疫吸附法 (ELISA)测定 12 8例糖尿病患者血清中谷氨酸脱羧酶 (GAD)抗体 ,其中 1型糖尿病患者 74例 (包括青少年患者 2 6例 ,成人迟发自身免疫型糖尿病患者 4 8例 ) ,2型糖尿病患者 5 4例。结果 1型糖尿病中青少年发病组GAD抗体阳性率为73 1% ,成人迟发自身免疫型糖尿病 (LADA)组GAD抗体阳性率为 75 0 % ,与 2型糖尿病组CAD抗体阳性率12 9%相比差异有显著性意义 (P <0 0 1)。结论 GAD抗体是 1型糖尿病自然病程中 β细胞功能损伤的一个预测指标 ,对糖尿病分型 ,指导治疗具有一定意义。

Objective To search the clinical significance of measuring GAD antibody in determining the type of diabetes.Methods Using ELISA method,we measured the serum levels of GAD antibody in groups of diabetic patients (group 1:26 classic type 1 diabetic patients;group 2:48 LADA patients;group 3:54 type 2 diabetic patients).Results It showed that the positive rate of GAD antibody in group 1(73 1%) and group 2(75%) were significantly higher than that of group 3(12 9%).Conclusion It suggests that GAD antibody is a valuable marker to predict the impairment of β-cell in type 1 DM.It might be useful in determining the type of DM and guiding the therapy.