回顾性分析临床两种常见葡萄球菌的耐药

Antibiotic Resistance of Two Kinds of Staphylococcus Commonly Encountered in Clinics: A Retrospective Study

目的 调查 1995～ 2 0 0 2年临床分离的两种常见葡萄球菌耐药情况 ,为临床用药提供参考。方法 应用回顾性调查分析方法 ,对我院 1995年 1月～ 2 0 0 2年 12月临床标本中分离的葡萄球菌进行统计分析。结果 8年间两种葡萄球菌共 5 2 5株 ,金黄色葡萄球菌、表皮葡萄球菌各占 5 6 .0 %及 4 4 .0 % ,耐甲氧西林的金黄色葡萄球菌(MRSA) ,表皮葡萄球菌 (MRSE)分离率分别为 82 .7%和 78.8% ;两种葡萄球菌耐药谱及 8年的耐药变化规律基本相同 ,对青霉素、苯唑西林、头孢唑林耐药率 >80 % ,对头孢唑林、红霉素、克林霉素、诺氟沙星的耐药率逐年增高 ,以诺氟沙星的耐药率增高最为明显 ,两种葡萄球菌皆对万古霉素敏感。

OBJECTIVE To study the antibiotic resistance of two kinds of staphylococcus commonly encountered in clinics. METHODS To study retrospectively the antibiotic resistance of staphylococcus that isolated from clinical samples from 1995 to 2002. RESULTS The proportion of Staphylococcus aureus and S. epidermidis was (82.7%) and 78.8% among 525 staphylococcus strains during the past eight years. The isolated rate of MRSA and MRSE was 63.3% and 70.2%. They had the similar changing in antibiotic resistance. The resistance rates to penicillin, oxacillin, cefazolin were above 80%. The resistance rates to cefazolin, erythromycin, clindamycin, norfloxacin had increased year by year. Staphylococcus was sensitive to vancomycin. CONCLUSIONS To strengthen the monitoring of the antibiotic resistance of staphylococcus is important for clinics.