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持久性豆状角化过度症1例 被引量:6

Hyperkeratosis lenticularis perstans
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摘要 报告1例持久性豆状角化过度症。患者男,48岁。因双手、足背和双下肢多发性淡红色角化性小丘疹18年就诊。组织病理检查示,表皮局灶性角化过度伴角化不全,其下方表皮萎缩变薄,真皮血管周围有较致密的单一核细胞浸润。外用0.025%维A酸软膏每日2次,2个月后皮损略变平。 A case of hyperkeratosis lenticularis perstans is reported. A 48-year-old man presented with the 18-year history of multiple, rufous and small papules on the back of hands and upper and lower legs. Histologic examination showed the foci of compact and eosinophilic hyperkeratosis overlying a thinned stratum malpighii. In the underlying papillary dermis there was a tight mononuclear infiltration. The patient was treated with topical 0.025% tretinoin twice daily for 2 months, which resulted in a slight applanation of the lesions.
机构地区 中国医学科学院
出处 《临床皮肤科杂志》 CAS CSCD 北大核心 2005年第3期167-168,共2页 Journal of Clinical Dermatology
关键词 豆状角化过度症 持久性 hyperkeratosis lenticularis perstans Flegel's disease
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参考文献3

  • 1Pearson LH, Smith JG Jr, Chalker DK. Hyperkeratosis lenticularis perstans (Flegel's disease). Case report and literature review[J]. J Am Acad Dermatol, 1987, 16(1 Pt 2): 190-195.
  • 2Jang KA, Choi JH, Sung KJ, et al. Hyperkeratosis lenticularis perstans (Flegel's disease): histologic, immunohistochemical, and ultrastructural features in a case[J]. Am J Dermatopathol, 1999,21(4): 395-398.
  • 3Price ML, Jones EW, MacDonald DM. A clinicopathological study of Flegel's disease (hyperkeratosis lenticularis perstans)[J]. Br J Dermatol, 1987, 116(5): 681-691.

同被引文献20

  • 1Price ML, Jones EW, MacDonald DM. A clinicopathologieal study of Flegel's disease (hyperkeratosis lentieularis perstans)[J]. Br J Dermatol, 1987, 116(5): 681-691.
  • 2Ando K, Hattori H, Yamauchi Y. Histopathological differences between early and old lesions of hyperkeratosis Lenticularis Perstans ( Flegl ' s disease ) . Am J Dermatopathol 2006 ; 28 : 122 - 126.
  • 3崔炳南,刘瓦利,李理.母女三人同患持久性豆状角化过度病[J].中华皮肤科杂志,2007,40(11):711-711. 被引量:2
  • 4Flegel H.Hyperkeratosis lenticularis perstans[J].Hautarzt,1958,9(8):363-364.
  • 5Krishnan A,Kar S.Photoletter to the editor:Hyperkeratosis lenticularis perstans (Flegel's disease) with unusual clinical presentation.Response to isotretinoin therapy[J].J Dermatol Case Rep,2012,6(3):93-95.
  • 6夏建新,王建伟,李蕾蕾,张民夫.持久性豆状角化过度症1例[J].中国麻风皮肤病杂志,2007,23(12):1100-1101. 被引量:1
  • 7Flegel H. Hyperkeratosis lentieularis perstans[ J ]. Hautarzt, 1958,9:363-364.
  • 8Buchner SA. Hyperkeratosis |enticularis pcl,'stans ( Flegcl's disease). In situ characterization of T cell subsets and Langerhans" cells[ J ]. Acta Derm Venereol, 1988,68 : 341 - 345.
  • 9Price ML, Jones EW, MacDonald DM. A clinicopathologi-cal study of Flegel's disease ( hyperkeratosis lenticularis per- stans) [ J]. Br J Dermatol, 1987,116:681-691.
  • 10van de Staak W J, Bergers AM, Bongaarts P. Hyperkeratosis lenticularis perstans (Flegel) [ J ]. Dermatol, 1980,161 : 340 - 346.

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