北方汉人重症肌无力及其不同亚型的遗传易患性与HLA-DQB1基因多态现象的相关研究

Study on the association Northern Chinese MG and subgroups Genetic susceptibility to HLA-DQB1 gene polymorphis

为了探讨北方汉人HLA—DQB1基因和重症肌无力的遗传易患性的相关性 ,运用PCR—SSP基因分型法 ,对 5 3例MG患者及 5 0名健康对照组HLA—DQB1基因进行分型。结果患者组 (包括亚型组 )和健康对照组比较 ,DQB1 0 30 3频率在患者组中明显增高 ,而患者组以及不同亚型组与对照组比较都有DQB1 0 6 0 1和DQB1 0 6 0 2频率明显降低 ,差异都有显著性意义。结果显示DQB1 0 30 3与MG的易患性有关 ,而DQB1 0 6 0 1和DQB1 0 6 0

To evaluate the susceptibility of HLA—DQB1 Polymorphism to Myasthenia gravis (MG) in the area of Northern China by The result showed that PCR—SSP was used to detemine the HLA—DQB1 genotype of 53 MG Patients and 50 healthy controls . The result showed that in comparison with the frequency of HLA—DQBI alleles between MG Patients (included subgroups ) and the healthy controls ,the frequency of DQB1 0303 was significantly increased, while the frequencies of DQB1 0601 and DQB1 0602 were significantly decreased. And these differences were statistically significant. It is suggested that DQB1 0303 was susceptible to MG; DQB1 0601 and DQB1 0602 were protective genes.