血清α-L-岩藻糖苷酶活力测定诊断原发性肝癌探讨

ACTIVITY DETERMINATION OF SERUM a - L - FUCOSIDASE IN DIAGNOSING PRIMARY HEPATIC CARCINOMA

目的:探讨血清α-L-岩藻糖苷酶(AFU)活力测定诊断原发性肝癌的价值。方法:测定正常人、各种肝病及肝脏以外恶性肿瘤患者血清AFU。结果:原发性肝癌(PHC)患者血清AFU检测阳性率达79.4％,与各对照组相比较,差别有统计学意义(P<0.05)。结论:AFU可作为PHC的血清标记物,其敏感性为79.4％,特异性为90.2％,准确度为88.4％,对甲胎蛋白(AFP)阴性病例尤有诊断价值。

Objective: To determine the value of serum a - L - fucosidase (AFU) in diagnosing primary hepatic carcinoma. Method: The serum AFU of healthy individuals and patients with primary hepatic carcinoma and other malignant cancers outside liver. Results: A positive rate of the serum AFU was highly 79.4% in patients with PHC, which is significant by contrast with all control groups. Conclusion: AFU can be an indicator for primary hepatic carcinoma with a sensitivity of 79.4% , specificity of 90. 2% and accuracy degree of 88.4% . It is especially useful for AFP negative patients.