摘要
目的:研究癌基因c-myc在子宫内膜癌中的表达与子宫内膜癌发生、发展及预后的关系。方法:采用免疫组化(s-p)法检测10例增生子宫内膜、22例子宫内膜不典型增生、42例子宫内膜癌中c-myc基因表达。结果:c-myc在子宫内膜癌中的阳性率为26.19％(11/42)显著高于增生子宫内膜(均显阴性)及子宫内膜不典型增生(4.55％,1/22)中的阳性率(P<0.05,P<0.05);c-myc在子宫内膜癌中的表达与组织学分级、临床分期显著相关(P<0.01,P<0.05),但与肌层浸润深度及淋巴结转移无关(P>0.05,P>0.05)。结论:癌基因c-myc在子宫内膜癌的发生、发展及转归中起着重要作用。
Objective: To study the expression and clinical significance of oncogene c - myc in endometrial carcinoma as well as between their oncogene expression and the relations, development and prognosis, of endometrial carcinoma. Method: c - myc expression was detected by immunohistochemical techniqe(s- p method)in 10 cases of proliferate endometrium,22 cases of atypical hyperplasia and 42 cases of endometrial carcinoma, between their oncogene expression and the. Results: The positive - expression rate 26. 19% ( 1 l/42)of c - myc in endometrial carcinoma was higher significantly than that in proliferative endometriums (0/10) and atypical hyperplasias (4.55% ,1/22)(P<0.05, P<0.05). The expression of c- myc in endometrial carcinoma was associated with histologic grade and clinical stage (P<0.01 ,P<0.05) ,but it was not associated with the depth of myometrial tumor invasion and lymphonode metastasis(P>0.05,P>0.05).Conclusion:Oncogene c-myc maybe play the important role in the genesis .development and prognosis of endometrial carcinoma.
出处
《九江医学》
2003年第3期142-143,共2页
Jiujiang Medical Journal
