福州地区质粒介导淋球菌耐药性监测

Surveillance of Plasmid-mediated Resistant Strains of Neisseria Gonorrhoeae in Fuzhou

目的 :明确福州地区由质粒介导产生青霉素酶淋球菌 (PPNG)菌株和由质粒介导产生高度耐四环素的淋球菌 (TRNG)菌株的流行状况 ,以制定有效的淋病防治方案。方法 :采用纸片酸度法和MIC测定法连续检测 1 999年～ 2 0 0 2年间淋球菌分离株的质粒介导耐药情况。结果 :4年来 ,共检测了 698株临床分离的淋球菌菌株 ,PPNG流行率由 1 999年 2 2 %上升为 2 0 0 2年 8 72 % ,TRNG由 0 6%上升为2 0 69%。结论 :福州地区PPNG、TRNG检查率呈逐年上升趋势 ,持续监测淋球菌PPNG菌株、TRNG菌株的流行情况 。

Objective:To study the prevalent trends of plasmid-mediated resistance of Neisseria gonorrhoeae strains in Fuzhou from 1999 to 2002. Methods: The plasmid-mediated resistance to tetracycline (TRNG) were determined by agar dilution method and penicillinase-producing N. gonorrhoeae (PPNG) by acidometric method. Results: A total of 698 isolated gonococcal strains were tested in the past four years. The rates of PPNG increased from 2.2% to 8.72% and TRNG from 0.6% to 20.69%. Conclusion: The prevalence of plasmid-mediated resistant N. Gonorrhoeae increased year by year in Fuzhou. It is important to survey the plasmid-mediated resistant strains of Neisseria gonorrhoeae consecutively in controlling gonorrhea.