摘要
用硅原子代替有机药物中的某一碳原子.叫硅药（Sila-drug）,我们曾经将硅原子引入高效杀螨剂Torque-[（PhMe2CCH2）3Sn]2O,合成了Sila-Torque-[（PhMe2SiCH2）3Sn]2O及其羧酸酯。
18 tri[(methyldiphenylsilyl) methylene] tin aliphatic carboxylates and aryloxyacetateswere synthesized by reaction of bis [tri(methyldiphenylsilyl) methylene] tin oxides with correspond-ing carboxylic acides. The IR, ~1H, ^(29)Si and ^(119)Sn NMR were determined. The results of spectra datashowed that these compounds are four-coordination or ganotin compounds. For aryloxyacetates, thereis a liner relationship between chemical shift of ^(119)Sn NMR and Hammett constant (σ) of para-sub-stituent of the aryl groups: δ^(119)Sn=11.487σ+143.563,n=6,r=0.979.
出处
《有机化学》
SCIE
CAS
CSCD
北大核心
1993年第3期264-268,共5页
Chinese Journal of Organic Chemistry
基金
国家自然科学基金
