7-芳基-10-芳基(甲基)-8,9,10,11-四氢苯并[c]吖啶酮-8的合成

Synthesis of 7-Phenyl-10-Phenyl (methyl)-8, 9, 10, 11-tetrahydrobenz [c] acridin-8-one

许多吖啶类化合物具有良好的生理活性,除了经常表现出抗症活性以外,关于抗癌功效的吖啶合成也日益引起化学工作者的注意。我们曾研究了杂代吖啶酮及其衍生物的合成。

Hexahydrobenx[c]cridin-8-ones were synthesized from cgclicdiketone, α-naphthylamineand appropriate aromatic aldehydes in ethanol. Oxidation of the hexahydro-benz[c]acridin-8-onewith chromic anhydride in acetic acid affordes tetrahydrobenz[c]acridin-8-one.