△^4—3,6—二酮甾体结构单元合成的改进

An Improved Synthesis of Δ~4-3, 6-dione Steroidal Moiety

5-烯-3-酮,4-烯-3-酮和4-烯-3,6-二酮是甾体化合物中常见的A、B环结构。具有这些结构的化合物可作为进一步进行化学修饰的中间体。其中前两种结构的化合物可由其相应的5-烯-3-醇在不同的条件下氧化制得。

Oxidation of cholesterol (la) and 16, 17α-epoxy-3-hydroxy-△~5-pregnene-20-one (lb) tothe corresponding △~4-3, 6-diones has been achived in high yield by one-step process, using high nolarratio of Pyridinium Chlorochromate (PCC) buffered with sodium acetate.