异雷公藤内酯四醇的晶体结构

The Crystal Structure of Isotriptetraolide

雷公藤系卫矛科植物(TripterygiumWilfordii Hook,f),1972年Kupehan从中分得三种环氧二萜内酯类化合物,显示出较强的抗白血病活性。为了寻找低毒有效的类似物。我们从雷公藤根皮的乙醇提取液加水沉淀,将滤液浓缩用硅胶吸附,洗脱液反复经硅胶柱层析,分离到一种新的环氧二萜内酯。它是前文报道的雷藤内酯四醇的同分异构物。

The crystal structure of isotriptetraolide, C_(20)H_(26)O_8, was determined on the Rigaku AFC5R four-circle diffractometer. The space group was found to be P2_1with a=1.021(1),b=1.126(1),c=1.8209(9)nm,β=98.84(5)°, Vc=2.069(3)nm^3,Z=4. The structure was solved by the directmethods and refined to a final R=0.048 for 2979 observed MoK_α reflections with Ⅰ>3σ(Ⅰ).