3-取代-(1H)-嘧啶[1,2-α]喹啉-1-酮和2-取代嘧啶[1,2a]苯骈咪唑-4-(10H)-酮的简便合成法

A New Convienent Synthesis of 3-substituted-(1H)-Pyrimidine [1,2-a] quinoline-1-ones and 2-Substituted Pyrimidine [1,2-a] benzoimidazole-4-(10H)-ones

丙二酸亚异丙酯及乙烯基硫代缩酮均是重要的有机合成试剂。而新近开发的5-(双甲硫基亚甲基)丙二酸亚异丙酯(1)既具有丙二酸亚异丙酯的环状结构,又具有乙烯基硫代缩酮的结构特征,它是一种多功能新的合成试剂。

2-Aminoquinoline reacted with 5-bismethylthiomethylene or 5-methylthioalkylidene isopropylidenemalonates as one pot reaction to afford a new convienent synthesis of 3-substituted-(1H)-pyrimdine [1, 2-α]quinoline-1-ones. 2-Aminobenzoimidazole could also take place analogous reaction to give 2-substitutedpyrimidine [1, 2-α] benzoimidazole-4-(1OH)-ones.