非小细胞肺癌中p73的表达及意义

Expression and implication of p73 protein in non-small cell lung carcinoma.

目的 探讨p73蛋白在非小细胞肺癌(NSCLC)组织中的表达及临床意义。方法 NSCLC 40例,用免疫组化二步法检测组织标本中p73蛋白的表达,按组织学分类后进行统计学处理。结果 p73蛋白在肺癌组织中的表达和肺癌淋巴结转移癌组织中的表达均明显上调,分别与肺支气管粘膜上皮不典型增生的表达比较,差异均有极显著意义(P<0.01);p73蛋白的阳性表达在肺癌的不同病理类型及分化程度中比较,差异均无显著意义(P>0.05);p73蛋白阳性表达在伴有淋巴结转移的肺癌组织中与无淋巴结转移的肺癌组织中比较,差异有显著意义(P<0.05)。结论 p73蛋白表达上调可能是NSCLC发生的重要因素;p73蛋白在伴有淋巴结转移的肺癌组织和肺癌淋巴结转移癌组织中表达均上调,推测p73上调可能促进肺癌的浸润与转移,这一基因变化可作为肺癌恶化、预后不良的动态监控标志物。

Ocjective To study the expression of p73 protein in non-small cell lung carcinoma (NSCLC) and its clinical implication. Methods In 40 cases of NSCLC, two steps immunohistochemistry was used to detect the expression of p73 protein in tissue samples. Results The positive expression of p73 protein was up-regulated in NSCLC tissues and the lymph node metastatic cancer tissues, significantly different from that in the normal bronchial epithedium (P<0.01). There was no significant difference in the positive expression of p73 protein among different pathologic types and degrees of differentiation of lung cancer (P>0.05). There was significant difference in the expression of p73 protein between the lung cancer tissues with lymph node metastasis and those without lymph node metastasis (P<0.05). Conclusion The up-regulation of p73 protein expression is an important factor for development of NSCLC. The expression of p73 protein in the lung cancer tissues with lymph node metastasis and lymph node metastatic cancer tissues of lung cancer was up-regulated, which may deduce that up-regulation of p73 protein may promote the invasion and metastatis.