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胆固醇和脂肪酸对CYP7A1的调节 被引量：1

The Effect of Cholesterol and Fatty Acid on the Regulation of CYP7Al
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摘要 胆固醇7α-羟化酶是胆固醇转化为胆酸过程中的关键酶,对维持机体的胆固醇内环境稳定起着重要作用。胆固醇对7α-羟化酶有诱导作用,在种属之间有很大差异。新近发现胆固醇并不单独决定该酶的活性,膳食中的脂肪酸和胆固醇的组合最终决定该酶的活性。这些调节作用主要通过LXRα、RXRα和PPARα对胆固醇的7α-羟化酶在转录水平调节实现。 Cholesterol 7alpha-hydroxylase (CYP7Al) is the key enzyme during the conversion of cholesterol to bile acid, and it is important to maintain the stable level of cholesterol in body. Cholesterol can induce the activity of CYP7Al, but the effect has great difference among different strain. The recent research has found that cholesterol do not determine the activity of CYP7Al by itself only, it is the combination of cholesterol and fatty acid in diet that determine the activity indeed ultimately. These regulations are realized mainly by LXRα、RXRαand PPARαon the translation level.
作者 李燕 凌文华
机构地区 中山大学公共卫生学院营养系
出处 《中山大学研究生学刊（自然科学与医学版）》 2003年第4期7-12,共6页 Journal of the Graduates Sun YAT-SEN University(Natural Sciences.Medicine)
关键词 脂肪酸 胆固醇7Α-羟化酶 胆酸 酶活性 调节作用 LXRΑ RXRα PPARΑ CYP7A1 胆固醇代谢 临床意义 Cholesterol Fatty acid CYP7Al
分类号 Q554.7 [生物学—生物化学]
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参考文献10

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同被引文献5

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  • 2Левченко ВИ.Анемия новорожденных телят[J].Ветеринария,1990,3(3):50-52.
  • 3邹思湘.动物生物化学[M].北京:中国农业出版社,2005:71
  • 4丁玲,永福,索南道吉,张凌云.野血牦犊牛生理指标测定试验[J].中国畜牧兽医,2009,36(8):169-170. 被引量：9
  • 5郭俊焕,周良炎,吴全忠,袁增,陈克喜,徐梅倩.葡聚糖铁防治仔猪缺铁性贫血试验[J].天津农业科学,1999,5(3):4-7. 被引量：9

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中山大学研究生学刊（自然科学与医学版）
2003年 第4期

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