PGLC对小鼠致畸实验研究

The Experimental Study of PGLC on Teratogenic Potential in KM Mice

观察了乙交酯 -L -丙交酯 -ε -己内酯三元无规共聚物材料 (PGLC)对昆明种小鼠孕期和胎鼠的影响。结果表明 ,PGLCA组 (10 0 0mg/kg)、B组 (5 0 0mg/kg)、C组 (2 5 0mg/kg)各组孕鼠和胎鼠各项指标与阴性对照组 (C- ,PBS液每日 0 .5ml/鼠 )差异无显著性 (P >0 .0 5 ) ,与阳性对照组 (C+,CP ,14mg/kg)差异有高度显著性 (P <0 .0 1)。PGLC剂量在 10 0 0～ 2 5 0mg/kg范围内对小鼠生殖能力和胎鼠发育无明显影响。

The teratogenetic effect of Glycolide L Lactide Caprolactone Tri Component Random Copolymer(PGLC)on the development of the KM mice was studied.Results showed that there were no significant difference between PGLC treared groups(PGLC 1000mg/kg,PGLC 500mg/kg,PGLC 250mg/kg) and the negative control in all parameters( P >0.05),and that there were significant difference between PGLC treated groups and the positive control( P <0.01).PGLC has no significant effect on the fertily and embryonic development of mice at dose range of 250～1000mg/kg As a long-term drug carrier implanted into body,the PGLC has no reproductive toxicity.