H. pylori, Cydooxygenase and Gastro-duodenal Diseases

The studies on H. pylori infection and its effects on the development of peptic ulcer disease and gastric cancer have led to a new area of exploration, namely the role of cyclooxygenase in these pathogenic mechanisms. Cyclooxygenase is the most important enzyme in the local production of prostagladins in the stomach. What are the effects of H. pylori infection on expression of cyclooxygenase I/II (COX-I and COX-H)? How would COX expression affect of healing of ulcers when NSIAD or COX-II inhibitors are to be used? Is there a role of COX expression in the development of gastric cancers?