国际心血管药物与药理发展动态

Trends in the development of cardiovascular drugs and cardiovascular pharmacology

本文综述了近两年国际会议与文献有关心血管药物与药理的发展动态：（1）研究内源性心血管活性物质，促进新药研制，如血管内皮松驰因子（EDRF），多肽与神经肽，血小板激活因子（PAF），前列环素，血栓素A2，白三烯及其拮抗剂；（2）利用生物技术生产高选择性的抗血栓药1-PA；（3）发展新思路创制新的钙拮抗剂、新降压药、新的心肌保护药和抗氧自由基损伤药；（4）适应临床需要合成一药多用的药物；（5）研究制剂与药物化学构型发现线索研制新药。

The trends in the develop ment ofcardiovascular drugs and pharma cologyin the recent two years were reviwedas:(1)studying the endogenous cardiovas-cular active substances to promote thedeve-Iopment of new drugs,such as endotheli-um-derived relaxing factor(EDRF),poly-peptides and neuropeptides,platelet-activa-ting factor(PAF),PGl_2,TXA_2 and itsantagonists,LTs and its antagonists;(2)using biotechniques to produce highly selec-tive antithrombotie drugs:t-PA;(3)deve-loping new idea to create new calcium an-tagonists,new antihypertensive drugs,newcardioproteetive drugs against injury by ox-ygen free radicals;(4)synthesizing multi-ple-action drugs to meet clinical needs;and(5)studying drug preparation and ste-reo chemicalstructure of drugs to find cl-ues for better drugs.