针吸乳腺肿瘤细胞AgNOR的定量观察

QUANTITATIVE OBSERVATION OF AgNOR IN FINE NEEDLE ASPIRATION CYTOLOGY OF BREAST TUMORS

用银染法对41例针吸乳腺良恶性肿瘤细胞的AgNOR进行了形态定量研究,结果显示:乳腺癌细胞中AgNOR的数量明显高于良性肿瘤(P<0.001),且乳腺癌细胞AgNOR表现为大小不一,形态不规则及分布无规律性。提示AgNOR的数量、大小、形态及分布均反映了不同肿瘤的生物学特性。因此,AgNOR的定量对乳腺肿瘤针吸细胞学鉴别诊断具有重要的参考价值.

Nucleolar organizer regions (NOR) was counted by means of an argyrophilic technique (AgNOR) in fine needle aspiration cytology of 41 breast tumors,both benign and malignant. It was found that the number of AgNOR in the malignant cells was significantly higher than that in the benign cells and the dots of AgNOR were frequently irregular in shape and distri- butioruand heterogeneity in size. It is suggested that the number, shape .distribution and size of AgNOR may reflect proliferative activities of cells. AgNOR enumeration is useful in differentiated diagnosis of fine needle aspiration cytology of breast tumors.