核仁组成区嗜银蛋白与胃病关系的研究

STUDY ON THE RELATION OF AGNORs AND GASTRIC DISEASES

本文应用银染细胞核仁组成区(AgNORs)技术,对34例胃腺癌(GAC),96例不同病理类型胃炎进行 AgNORs 颗粒计数。结果显示:胃腺癌与各型胃炎均有显著性差异;胃粘膜癌前病变(本文指胃炎伴不典型增生(CGAH)。胃炎伴肠化(CGIM)慢性萎缩性胃炎(CAG))均与慢性浅表性胃炎(CSG)有显著性差异。故 AgNORs 在胃粘膜良恶性疾病的鉴别及癌前病变的诊断上具有一定意义。

Silver—gelatinet chnique for nucleolar organizer regions was used to quantitatively count the nuclear AgNORs in 34 cases of gastric adenocarcinoma and 96cases of gastritis with different pathological changes, The results show that the AgNORs count was significantly higher in gas— tric adenocarcinoma compared with various gastritis and precancerous lesion (including atypia proliferation,intestinal metaplasia,chronic atrophic gas— tritis)Thus th AgNORs count is valuable for diagnosis of benign and mali— gnant diseases of gastric mucosa and precancerous lesion.