摘要
本文对43例哮喘患者及20名正常人分别进行了血浆 TXB_26—keto PGF_(1a)放射免疫测定.其结果:哮喘患者发作期血浆 TXB_2明显高于缓解期,且哮喘者各期血浆 TXB_2均较正常人显著增高(P<0.05);病情越重,增高越明显;而6—keto PGF_(1a)各组间无显著差异(P>0.05)。结果表明血栓素 A_2可能在哮喘的发病机理中起着重要作用。
We determined the amounts of TXB2 and 6-keto-PGF_(1a) in plasma(RIA method)of 43 asthmatic patients and 20 healthy controls. The results showed that TXB2 levels in attacking asthmatics were obviously higher than that in stable asthmatics;and TXB2 levels in stable asthmatics were higher than that in healthy controls.More serious asthmatic conditions were,more higher TXB2 levels were.The amounts of 6—keto—PGF_(1a) were not different among three groups.This study is suggested that TXA2 may play an important role in the mechanisms of asthma.
