瘙痒症、神经性皮炎患者与其血浆中阿片样肽间关系

Relations between Opium Peptide in Plasma and Pruritus and Vidal Disease

目的：阿片样肽参与许多与精神因素相关的疾病的病理过程，为了探讨瘙痒症，神经性皮炎与阿片样肽间的关系。方法：我们采用放射免疫法测定了49例瘙痒症患者、33例神经性皮炎患者及29例健康献血员的血浆β－内啡肽、脑啡肽、强啡肽的浓度（因实验药盒的使用时间所限，所以分两期进行）。第一期测定了20例痊痒症患者．17例神经性皮炎患者及20例健康献血员的血浆β－内啡肽，脑啡肽的水平；第二期测定了29例瘙痒症患者、16例神经性皮炎患者及9例健康献血员的血浆强啡肽水平。结果：瘙痒症患者β－内啡肽及强啡肽水平均明显高于正常对照组，脑啡肽水平与正常组无显著差异；神经性皮炎患者的血浆β－内啡肽，脑啡肽水平均明显高于正常对照组．而强啡肽水平与正常组无显著差鼻。结论．对片样肽确实与瘙痒症、神经性皮炎的发病有关。

Aim:To discuss the relations between opium peptide and pruritus and pruritus and Vidal disease as opium peptide might take part in the pathological process in some mental related diseases.Methods:49 cases of pruritus, 33 cases of Vidal disease and 29 cases of normal were measured their β - endophin, enkephaline and fortiphin. Results: β - endophin and fortiphin were higher in pruritus than control group and enkepaline was almost same.β - endophin and enkephaline were higher in Vidal disease than control group and fortiphin was almost same.Conclusion:The opium peptide should be relative with the onset of pruritus and Vidal disease.