胆红素致兔脑瘫动物模型的脑干听觉诱发电位研究

A Study on Brainstem Auditory Evoked Potentials in Animal Model of Cerebral Palsy of Rabbits Induced by Bilirubin

目的：应用脑干听觉诱发电位对胆红素致脑瘫兔的听路损害情况进行探讨。方法：对５例脑瘫兔和１０例同日龄正常兔的脑干听觉诱发电位进行检测。结果：脑瘫兔组Ｐ３波出波率低于正常兔组（Ｐ＜０．０１）；听路损害均呈双侧性，周围性听路损害２只耳，中枢性听路损害３只耳，混合性听路损害５只耳；脑瘫兔组Ｐ１、Ｐ２、Ｐ３、Ｐ４波潜伏期延长（Ｐ＜０．０１），Ｐ１～Ｐ５波幅两组间差异不显著（Ｐ＞０．０５），Ｐ１～Ｐ２、Ｐ１～Ｐ４峰间潜伏延长（Ｐ＜０．０１），Ｐ１～Ｐ３、Ｐ１～Ｐ５两组间差异不显著（Ｐ＞０．０５）。结论：胆红素致脑瘫兔的脑干听觉诱发电位改变呈双侧性；为蜗后性损害，且以混合性听路损害为主。

Objective:To study the auditory pathway lesions in cerebral palsy rabbits induced by bilirubin by brainstem auditory evoked potentiasl(BAEP).Methods:BAEP was recorded in 5 cerebral palsy rabbits and 10 normal rabbits the same age.Results:The rate of wave P 3 presence of the cerebral palsy group was lower than that of the normal group(P<0.01). The abnormalities of BAEP contained three types:impairment in peripheral auditory pathway(2 ears);impairment in brainstem pathways(3 ears);complex defects of both auditory pathways(5 ears).Prolonged latencies of waves P1,P2,P3,P4 and longer interpeak latency of wave P1～P2 and P1～P4 were observed (P<0.01).There were no significant differences in the amplitude of waves P1～P5 between the cerebral palsy group and the normal group(P>0.05).Conclusion:The auditory pathway impairment of cerebral palsy rabbits induced by bilirubin was bilateral and retrocochlear;complex defects of both auditory pathways predominated.