直流电药物导入疗法的实验研究

Experiment Research on Direct Current Medicine Leading Therapy

目的：为探讨物理因素对离子型和非离子型药物透皮的影响。方法：用强离子型药物青霉素钠和弱离子型药物乙酸，分别在不同摩尔浓度下作自由扩散和电泳实验，分别计量扩散距离和电泳速度。结果：药物自由扩散不受电场力的影响，其扩散速度与浓度成正比，在同场强下离子电泳速度与分子量成反比，青霉素离子运动速度为０．２６ｍｍ／ｈ（０．０７ｃｍ×１０－４／ｓ）；乙酸运动速度为０．３３ｍｍ／ｈ（０．０９ｃｍ×１０－４／ｓ）。结论：在药物导入时宜用高浓度溶质以提高前沿离子数量，增加药物导入量。

Objective:To stude the sway of physical factor to dermapermeability of ionic and nonionic drugs.Methods:Penicillin sodium(fortis inoic drug)and acetic acid(weakly ionic drug)were evaluated by electrophoresis and free diffuse at vary kinds of mole consistence,meanwhile,distance of diffuse and speed of electrophoresis were measured.Results:Free diffuse of drugs were not effected by electric field power.Diffuse speed was direct ratio to mole consistence and the electrophoresis speed was inverse ratio to amounts of molecule at the same electric field power.The speed of penicillin ion movement was 0.26 mm/h(0.07 cm10-4/s),the speed of acetic acid movement was 0.33mm/h(0.09 cm10-4h/s).Conclusion:It is so better for high consistence adopted when drugs are conducted that the amounts of preceding ion could be increased,however,the amounts of conducted drug enhanced.