卵巢肿瘤细胞DNA及RNA含量的定量分析及其临床意义

Analysis of cellular DNA and RNA contents in ovarian tumors and its clinical significance

本资料对９３例不同性质的卵巢肿瘤细胞ＤＮＡ及ＲＮＡ含量进行了定量研究，其中５０例良性、４３例恶性。并对患者进行１～５年的随访。结果是卵巢良性肿瘤的异倍率（假阳性）为４４％，恶性肿瘤异倍率为８６．０％。以“标准ＤＩ”及“标准ＲＩ”为指标判断卵巢肿瘤性质的准确率较以“异倍性”为高，且双指标同时应用高于任一单指标：对卵巢良恶性肿瘤的诊断准确率分别为９０％和９５．３％。提出“标准ＤＩ”和“标准ＲＩ”是判断卵巢肿瘤性质的理想指标。且ＤＮＡ及ＲＮＡ含量与卵巢癌预后有密切关系。

The cellular DNA and RNA Cont ents of 93 ovarian tumors in varied biological nature have been studied by the method of flow cytometry.Among them, 50 were benign and 43 were malignant. All patients have been followedup for one to five years,The results were that the aneuploid rate(pseudoposition)in ovarian benign tumors was 44%,and 86% in malignant.Statistically, the accurate ratioes of the parameters by the “standard DNA index”and“standard RNA index”to indicate the nature of ovarian tum0rs were respectively more sensitive than by 'aneuploidy'. In addition,the accurate ratio by double parameters was better than any single one: it can predicate 90%in benign and 95.3%in malignant.We suggest that the 'standard DNA index' and “standard RNA index' are the more reasonable parameters forward in predicating the biological nature of ovarian tumors.