肝硬化门脉高压与一氧化氮

Relationship between Portal Hypertension and Nitric Oxide in Patients with Liver Cirrhosis

目的 :探讨肝硬化门脉高压 (PTH)的血流动力学变化及其与血中NO的关系。方法 :48例肝硬化PTH病人 (代偿期 18例 ,失代偿期 30例 )及 32例正常人作为研究对象 ,应用双功能多普勒测定门静脉血流量(PVBF)、脾静脉血流量 (SVBF) ,同步测定血中NO的水平 ,并分析PVBF、SVBF与NO的相关性。结果 :肝硬化组PVBF、SVBF及NO均明显高于对照组 ,且PVBF、SVBF与NO关系密切。结论 :门脉系统高血流动力学改变存在于肝硬化PTH发病的始终 ,NO的生成增多可能在门脉高压的形成、维持、加重中发挥重要的作用 。

Objective:The aim of this study is to find out the relationship between portal hypertensions and a vasoactive substance-nitric oxide(NO)) in the liver cirrhosis (LC) patients. Methods: 48 LC patients (including 18 with compensated LC and 30 with decompensated LC) and 32 normal controls(NC)were studied. Color duplex doppler ultrasonography was used to study portal venous and splenic venous blood flow (PVBF and SVBF) and the blood concentration of NO was detected. We then analyzed the correlation between PVBF and SVBF and NO. Results: PVBF, SVBF and NO increase significantly as compared with control, PVBF and SVBF correlate with NO in LC. Conclusion: Portal hyperdynamy can be found in the cirrhosis patients from beginning to end, possibly because of higher production level of NO, which is useful for the clinical diagnosis and treatment of the disease.