肝硬化病人并发上消化道出血时体内TNF-a的变化

Changes of TNF-a in Liver Cirrhosis Patients with Upper Gastrointestinal Bleeding

目的 :了解乙肝后肝硬化 (LC)患者外周血肿瘤坏死因子 -a(TNF -a)水平在并发上消化道出血中及止血后的差异。方法 :用双抗夹心酶联免疫法测定其外周血TNF -a的水平。结果 :肝硬化病人出血期TNF -a及心率 (HR)均明显高于正常 ,且与HR呈正相关 ,与收缩压 (SP)呈负相关 ;TNF -a在止血后更高。结论 :出血是肝硬化病人TNF -a升高的重要原因 ,TNF -a的升高对止血是否有利尚不清楚 ,可能与出血后肝功能的恶化有关。

Objective: To investigate changes of TNF-a in patients of liver cirrhosis (LC) with upper gastrointestinal bleeding. Mathods: TNF-a was determined with enzyme linked immun-osorbent assay. Results: The levels of TNF-a and HR in patients were signifcantly higher than that in normal control, and there was a positive correlation between TNF-a and HR and a negtive correlation between TNF-a and BP. The level of TNF-a in LC patients with bleeding was specially higher when bleeding was stanched. Conclusion: upper gastrointestinal bleeding is an important cause for high level TNF-a in LC, which might relate to deterioration of liver function after bleeding stanched. It is unclear whether TNF-a is helpful to hemostasis in these patients or not.