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云芝糖肽的干扰素诱生和促诱生效应 被引量:1

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摘要 云芝糖肽(Polysaccharide-Peptide,Ps-P)是与日本产品Kredtin(Ps-K)相类似的云芝糖肽,它的产生菌属担子菌纲、多孔菌目、多孔菌科革盖菌属,学名为彩绒革盖菌(Corolus Versi-color)由杨庆尧从上海的柳树倒木上分离所得,现已证明所提取的糖肽成分能提高红细胞的免疫功能,并具有抗肿瘤和免疫调节作用。我们用Ps-P在体外进行了干扰素(IFN)诱生和促诱生试验,证明Ps-P是IFN-α的诱生剂,又是IFN-α和IFN-γ的促诱生剂,现报告如下:
出处 《苏州医学杂志》 1995年第4期4-5,共2页
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  • 1王皓,邹正辉,汪涛,王洪云,顾振纶.云芝糖肽对小鼠骨髓粒─单系细胞的影响[J].苏州医学院学报,1996,16(4):601-603. 被引量:5
  • 2李丽美,杨晓彤,糜可,杨庆尧.Fas在云芝糖肽诱导HL-60细胞凋亡中的作用[J].上海师范大学学报(自然科学版),2007,36(1):60-64. 被引量:4
  • 3闫丽,李秀惠,谢立,时红波,辛咏梅,贺立香.慢性乙型、丙型肝炎混合感染患者血清IL-2及TNF-α水平的研究[J].天津医药,2007,35(6):446-447. 被引量:2
  • 4Yang QY. Yun Zhi Polysaccharopeptide ( PSP ) and the general aspects of its research [ J ]. Fung Sci, 1997,12 ( 1/2 ):1-8.
  • 5Hirobumi Asai, Hiroko Iijima, Kenichi Matsunaga, et al.Protein- bound polysaccharide K augments IL-2 production from routine mesenteric lymph node CD4^+ T cells by modulatingT cell receptor signaling [ J ] .Cancer Immunol Immunother, 2008,57: 1647-1655.
  • 6Wong CK, Tse PS, Wong EL, et al.Immunomodulatory effects of yunzhi and danshen capsules in health subjects-a randomized, double -blind, placebo-controlled, crossover, study[ J ] .Immuno-pharmacol, 2004 ( 2 ): 201-211.
  • 7Chan SL, Yeung JH. Polysaccharide peptides from COV-1 strain of Coriolus versicolor induce hyperalgesia via inflammatory mediator release in the mouse[ J ] .Life Sci,2006,78 ( 21 ): 2463-2470.
  • 8Masashi Kanazawa, Yayoi Mori, Kazue Yoshihara, et al: Effect of PSK on the maturation of dendritic cells derived from human peripheral blood monocytes[ J ] . Immunology Letters,2004,91 : 229-238.
  • 9Yoshio Ohmura, Keniehi Matsunaga, Isamu Motokawa, et al. Proteeti-Ve effects of a Protein-Bound Polysaceharide, PSK, Againse Candida albi-eans Infection in Syngeneie Tumor- Bearing Mice Via Thl Cell Functions[ J ] .Cancer Biotherapy & Radiopharmacentieals, 2003,18 ( 5 ): 769-781.
  • 10Ho C~', Lau CB, Kim CF, et al. Differential effect of Coriolus versicolor ( Yunzhi ) extract on cytokine production by murine lymphocytes, invitro[ J ] .International Immunopharmacoly, 2004,4 ( 12): 1549-1557.

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