摘要
本研究旨在探讨卡托普利(Cap)对离体缺血再灌注鼠心心律失常的作用。结果表明,对照组缺血后再灌注初期心律失常发生率高达91.67％(11/12),Cap组仅为30.77％(4/13),两组比较有明显差异(P<0.005);对照组心律失常持续时间明显长于Cap组(P<0.001),前者为27.91±6.94min,后者1.88±1.38min。上述结果提示,Cap具有显著的抗缺血再灌注性心律失常作用。
The effects of captopril(Cap) on ischemia/reperfusion arrhythmias after a 10-min glo- bal ischemia (stopping perfusion) followed by a 30-min reperfusion were investigated in Lan- gendorff rat hearts. Our results showed that the incidence of reperfusion arrhythmias in the control group was 91.67％ (11/12), greatly higher than the 30.77％(4/13) in the Cap group (P<0.005), during the reperfusion period. The reperfusion arrhythmias lasted significantly longer in the control group than in the Cap group. (27.91±6.94 min and 1.88±1.38 min. respectively). These data suggest that Cap (0.2mmol/L) could remarkably reduce the sus- ceptibility to reperfusin-induced arrhythmias, especially to ventricular fibrillation.
关键词
卡托普利
药理学
心律失常
Captopril/pharmacol
Ischemia/reperfusion
Arrhythmia/drug ther
