矽肺宁及其组分抗石英毒的实验研究

EXPERIMENTAL STUDIES ON THE DEFENSIVE ACTION OF XIFEINING AND ITS COMPONENTS AGAINST QUARTZDUST

本文采用体内外毒性实验方法,研究了矽肺宁及其两大组分(组分A与组分B)的抗石英毒作用,并探讨了其作用机理。实验结果表明,矽肺宁两大组分均能明显减轻石英毒作用,两组分作用方式有所不同,组分A的作用主要是抗炎和弱保护细胞膜效应;组分B的作用主要是保护细胞膜。同时,未能证实矽肺宁抑制脂质过氧化的作用是通过直接清除·O_2来实现的。本研究结果为矽肺宁的推广应用和矽肺宁与其他药物联用治疗矽肺提供了必要的实验依据。

The defensive action of Xifeining and its two main components against quartz toxicity were studied experimentally both in vivo and in vitro. The results showed that the two chief components of Xifeining significantly reduced the cytotoxicity induced by quartz dust. How- ever, the mechanism of the two components was different. It was demonstrated that compo- nent A exerted its influence by means of anti-inflammatory activity and a weaker protective action on the membrane, while component B was an effective cellular membrane protectant. The result also indicated that the inhibitive effect of Xifeining on lipoxide was not produced directly by scanning. O_2. The conclusion provided essential evidence for the feasibility of wide application of Xifeining and its combination with other medicines in the treatment of silicosis.