摘要
40只NIH小鼠分为单用阿霉素20mg/kg、两种不同剂量维生素E分别合用阿霉素、以及对照共4组。合用维生素E组小鼠存活时间显著长于单用阿霉素组小鼠,病理切片光镜检查结果显示,合用维生素E组小鼠心肌病变程度显著减轻。本实验结果提示维生素E能减轻阿霉素引起的小鼠心脏毒性。
40 NIH mice were treated with 20mg/kg of doxorubicin ip with and without vitamin E to examine the effect of vitamin E on doxorubicin-induced cardiotoxicity. Coadministration of vitamin E resulted in prolongation of survival period. The light microscopic examination of myocardial tissue from the mice treated with both doxorubicin and vitamin E revealed a marked diminution of vacuolization. The results suggest that vitamin E is effective in redu- cing doxorubicin-induced cardiotoxicity in mice.
基金
浙江省自然科学基金
关键词
维生素E
阿霉素
毒性
心肌
Vitamin E/drug eff
Doxorubicin/tox
Myocardium/pathol
Mice
