益气活血化痰法对血管性痴呆大鼠脑组织中内皮素和降钙素相关基因肽的影响

Effect of Yi Qi Huo Xue Hua Tan Principle on The Levels of ET-1 and CGRP of Brain Tissue in Vascular Dementia Rats

目的 :通过对VD大鼠脑组织ET 1和CGRP含量的测定 ,探讨其在VD形成过程中的发病机制和中药干预机制。方法 :采用放射免疫分析法测定脑组织ET 1和CGRP浓度。结果 :1 模型组、正常组与假手术组比较ET 1含量升高 ,CGRP含量降低 ,均有非常显著性差异 (P <0 0 1) ;2 大剂量组ET 1含量变化较治疗前明显降低 ,CGRP含量较治疗前明显升高 ,均有非常显著性差异 (P <0 0 1)。讨论 :VD在形成过程中ET 1含量增高 ,CGRP含量降低 ,失去二者的平衡 ,中药能有效调节二者的平衡 ,是防治VD的可能机制之一。

Objective:To explore the mechanism of Yi Qi Huo Xue Hua Tan Principle on the levels of ET 1 and CGRP of Brain Tissue in vascular dementia rats.Method:The levels of endothelin 1 and calcitionin gene related peptide (CGRP) were measured by radioimmunoassay.Results:1.The model group compared with the control,ET 1 level increased markedly,and CGRP level decreased markedly.2.The therapeutic group can reduce the release of ET 1 and increase the level of CGRP.Conclusion:Yi Qi Huo Xue Hua Tan Principle can balance between two levels,which is one of the mechanisms to treat Vascular Dementia(VD).