皮毛粉尘对大鼠肺纤维化作用的实验研究

The experimental study on fibrogenicity of fur dust on rat lung.

本文用皮毛作业现场粉尘(游离SiO_2含量分别为0.6%、0.7%和17.6%)经大白鼠气管内染尘,于染尘后1、3、6、12个月作肺组织病理学检查及全肺胶原含量测定。实验动物早期主要改变为间质肺炎样改变和呼吸遗炎症。实验晚期时,游离SiO_2含量低于1%的皮毛粉尘只表现为肺间质纤维增生,而游离SiO_2含量为17.6%的皮毛粉尘同时在肺内有典型的纤维结节形成,肺组织超微结构有相应改变。证明皮毛粉尘具有一定致纤维化作用,致纤维化作用的强弱与粉尘中游离SiO_2含量有关,提示应引起对皮毛作业工人尘肺的重视。

The rats were injected intratracheally with fur dust from working place (silica content was 0.6%, 0.7%, 17.6% respectively). At the end of 1, 3, 6, 12 month, histological changes of lung were examined and lung collagen contents were determined. The result showed that interstitial pneumonitis and respiratory inflammation in lung were observed in early stage. At the end of 12 month, the fur dust with low silica content (lower than 1%) caused slightly interstitial proliferation in lung, whereas fur dust with higher silica content (17.6%) cause typical fibrotic nodulls, The ultrastructual changs of lung had paralled alteration. On the base of above experimental data, it might conclude that the fibrogenicity of the fur dust was mainly related to silica content, and that the pnumoconiosis due to fur dust exposure should not be ignored.