小活络丸中乌头碱的溶出度研究

Study on Dissolution Rate of Aconitine from Xiaohuoluo Pills (Radix Aconiti, Radix Aconiti kusnezoffii, etc.)

本文探讨了测定小活络丸中乌头碱溶出度的方法。用浆法,以pH3的70％乙醇液为介质,转速为100r.p.m。将乌头碱的相对累积溶出率与用生物法测定小活络丸在小鼠体内的吸收率做相关性分析,结果显示二者间有极显著的线性相关性。说明用本方法测定乌头碱的溶出度参数对评估小活络丸的内在质量有实用价质。

The determination method,using paddle method, for dissolution rate of aconitine from Xiaohuoluo Pills was studied (medium: 70% alcohol, pH3, rotation speed: 100. r. p. m). The correlation analysis showed a significant linear correlation between relative accumulative rate of dissolution of aconitine and in vivo absorbility of Xiaohuoluo Pills in mice by biological determination,which indicates that the parameter of dissolution rate of aconitine obtained by this method is of practical value for interior quality evaluation of Xiaohuoluo Pills.