鼻咽癌病人血浆脂质过氧化物、IL-2及IL-2受体活性的研究

Plasma lipid peroxide, activity of IL-2 and IL-2 receptor in patients with nasopharyngeal carcinoma (NPC)

本文对不同病期鼻咽癌(NPC)病人血浆中脂质过氧化物—丙二醛(MDA)、外周血淋巴细胞产生IL-2的能力、IL-2受体活性进行初步探讨。结果显示NPC病人血浆中MDA含量较正常人明显增高(P<0.01),晚期病人比早期病人增高更明显(P<0.01);患者外周血淋巴细胞分泌IL-2的能力及IL-2受体活性较正常人明显下降(P<0.01)。这提示了NPC患者血浆中MDA的增高和肿瘤的发生发展有关,NPC患者免疫功能的下降可能与MDA的升高有关。

Changes of plasma lipid peroxide, production of IL-2 and activity of IL-2receptor of peripheral blood lymphocytes in patients with nasopharyngeal carcinoma(NPC) were reported. The results showed MDA levels in plasma from 35 cases of NPCwere much higher than those of healthy controls (P<0.01). The elevated level of MDAin the late phase of the disease was higher than that in early phase (P<0.01). The pro-duction of IL-2 and activity of IL-2 receptor of peripheral blood lymphocytes of 22cases NPC was much lower than those of healthy controls (P<0.001). It might suggestedthat there was a relation between plasma lipid peroxide and NPC. The elevated MDAlevel may play a role as an immunologic inhibitory factor to suppress the ability oflymphocytes to produce IL-2.