花粉对谷氨酸钠所致小鼠肥胖的预防作用

Preventive effect of pollen on obesity of MSG-mice

初生乳鼠自出生当天起皮下注射谷氨酸钠2mg/g,连续5天,可复制成小鼠肥胖模型,表现为至6周龄后可发生进行性肥胖。自4周龄断乳后(即肥胖发生前)开始灌喂花粉5～10g/kg,连续30天,对小鼠肥胖有明显的预防作用。花粉预防组的体重和肥胖指数(Lee's Index)明显低于不用花粉的致肥组,并能显著降低血清和肝脏胆固醇与甘油三酯及体内脂肪含量。本文结果提示花粉可能有益于肥胖症的预防,值得临床试用。

Preventive effect of pollen, (at 5～10g/kg/d orally for 1 month) on obe- sity and elevation of lipid in serum and liver was observed in obese mice induced by sub- cutaneous injection of L-monosodium glutamate (MSG)2 mg/g from 1st to 5th day after birth. The results showed that in MSG-treated mice the body weight and weight of fat in groin, around kidney, and in abdominal cavity and also the Lee's index were all redu- ced by pollen given orally before onset of obesity caused by MSG and during development. The total cholesterol and triglyceride levels in serum and liver were much higher in the MSG mice than normal mice. These results indicated that ora1 administration of pollen could prevent obesity of MSG treated mice.