平阳霉素瘤内注射治疗口腔颌面部血管瘤临床观察

Clinical observation of pingyangmycin intratumor injection for patients with oral and maxillofacial hemangioma

目的 :观察平阳霉素局部注射治疗口腔颌面部血管瘤的疗效及不良反应 ,分析影响疗效的因素。方法 :将平阳霉素 8mg+ 2 %利多卡因注射液 4m L +地塞米松 5 m g配制成注射剂 ,根据病变部位、瘤体大小及患者年龄酌情注入以上制剂 1m L～ 5 m L,每隔 7d重复用药一次 ,直至治愈为止 ,总药量一般不超过 5 0 m g。结果 :本组 40例 ,随访观察90 d～ 2 a,显效 2 8例 ,有效 10例 ,无效 2例 ,无 1例发生肺毒性反应。结论 :平阳霉素瘤内注射治疗口腔颌面部血管瘤方法简便、安全、疗效确切 ,尤其适用于毛细血管型。

Objective:To observe the effect and the adverse reaction of pingyangmycin intratumor injection for patients with oral and maxillofacial hemangioma,and analyze the factors affecting prognosis.Method:8 mg of pingyangmycin was dissolved in 4mL of 2% lidocaine hydrochloride and 1mL of dexamethasone,the volume of the solution injected into tumors was changed from 1 to 5 mL.based on the dfferent site,volume of hemangioma and age of patient.The drug can be used once again in one week with a total dose not more than 50mg.Result It showed marked effectiveness in 28 of 40 cases (70%),immprovement in 10 of 40 cases(25%) and failed in 2 of 40 cases(5%) in three months to two years follow-up.None suffer from pulmonary toxic reaction.Conclusion:This result indicated that pingyangmycin intratumor injection is a choice for treating oral and maxillofacial nemangioma.It is especially suitable for facial capillary hemangioma mixed hemangioma and cavernous nemangioma of small and middle size.