太极拳运动对高脂血症合并Ⅱ型糖尿病患者的疗效观察及其机理探讨

Effects and Mechanism of Tai Chi Exercise on Hyperlipidemia and Diabetes Ⅱ

观察太极拳运动对高脂血症合并Ⅱ型糖尿病的疗效，并对其机制进行探讨。方法：对１２例老年高脂血症合并Ⅱ型糖尿病患者，进行为期８周监督下的太极拳运动锻炼，观察各组锻炼前、和８周锻炼后一次性安静空腹状态下，以及一次性运动后即刻空腹状态下血浆脂质、血糖（ＧＬＵＫ）、胰岛素（Ｉｎｓ）及红细胞胰岛素受体（ＩｎＲ）等指标的变化。血脂、血糖、胰岛素的测定用临床常规检验法，红细胞胰岛素受体用改良Ｇａｍｂｈｉｒ法。结果：（１）经过８周锻炼后，安静状态下前后对比：甘油三酯（ＴＧ）、ＧＬＵＫ水平都显著下降（Ｐ＜０．０５），ＨＤＬ—Ｃ水平、ＩｎＲ数目及结合容量显著升高（Ｐ＜０．０５），而 Ｉｎｓ、ＴＣ、ＡｐｌＡＩ、ＡｐｏＢ水平未见显著变化 ；（２）锻炼 ８周结束时，一次性运动后即刻与当天运动前安静状态下比较：ＴＣ、ＡｐｏＢ水平极显著升高（Ｐ＜０．０１），ＨＤＬ—Ｃ水平。ＧＬＵＫ、ＩｎＲ数目和结合容量显著升高（Ｐ＜０．０５），Ｉｎｓ、ＴＧ、ＡｐｏＡｌ水平未见显著变化。结论：（１）长期太极拳运动可以有效降低高脂血症患者合并Ⅱ型糖尿病患者的 ＴＧ水平，升高 ＨＤＬ－Ｃ水平和 ＨＤＬ—Ｃ／ＴＣ比值，改善脂代谢紊乱；（２）长期太极拳运动在维持正常的

Ojbective: To observe effect of Tai chi exercise on hyperlipidemia with diabets Ⅱ,and eluci- date its mechanism. Methods: 12 subjects with hyperlipidemia and diabetes Ⅱ were trained with Tai Chi exercise for 8 weeks. And then do acute exercise of Tai Chi at the end of 8th week. To differenti- ate between transient (acute) and training (chronic) effects of Tai Chi exercise on the two groups re- spectively. Result: (1 ) By 8 weeks Tai Chi exercise, the serum levels of triglycerides (TG) and glucose (GLUK) decreased obviously (p <. 0. 05 ), the serum levels of HDL - C, and insulin-receptor (InR) numbers and its binding volumes increased obviously (p< 0. 05 ), but TC, ApoAl, ApoB, Insulin (Ins), did not change obviously. (2) After the acute Tai Chi exercise on the end of 8th week, the serum levels of TC and ApoB increased greatly (p< 0. 01 ), and HDL - C, GLUK, InR numbers and its binding vol- umes increased obviously (p< 0. 05 ), but TG, ApoAl and Ins did not change obviously. Conclusion: (1) Long term TaiChi exercise decreased TG level, wherease increased HDL - C levels(or HDL - C/ TC) effectively of hyperlipidemia with diabetes Ⅱ. (2) Long term TaiChi exercise decreased serum GKUK levels effectively while maitaining Ins still in normal level. (3) Tai Chi exercise improved the metabolism of serum lipid and glucose effectively on hyperlipidemia with diabetes Ⅱ by decreasing in- sulin resistance.